Launched in 2000 by the french Ligue Nationale Contre le Cancer, and based on a proposal from Pr François Sigaux, the Cartes d’Identité des Tumeurs research program (CIT) aims at characterizing exhaustively the cancer-driving genomic alterations. These abnormalities can be deeply analysed thanks to the development of high-throughput biological techniques and results in a better understanding of the mechanisms driving each cancer type. Our work establishes a strong basis for the development and improvement of precision medecine, with the purpose of providing a clinical care adapted to the genomic characteristics of each tumor.
The CIT program relies on 3 major assets :
- a national network involving numerous fundamental and clinical research teams. This network is essential to access biological ressources from larger cohorts of patients for various cancer types. Those experts in oncology take an active part in guiding and supervising the projects led by the CIT program.
- A technological platform dedicated to the extraction of genetic material (DNA, RNA, …) for each project as well as their transfert to profiling / sequencing platforms. This ensures a standardized protocol for each biological samples analysed through the program. The associated clinical data are also collected and curated following an established rigorous protocol.
- A team of skilled bio-analysts with a high expertise on the tools and methods adapted to the analysis of biological data, but also a deep knowledge of cancer biology. This team is in charge of the integrative analysis of the genomic data generated in order to achieve a molecular dissection of the various tumor types and further interpret the data.
The combined analysis of chromosome abnormalities, transcriptome, methylome, miRnome and exome data, results in an integrated view of the mechanisms involved in tumorigenesis.
More than 14’000 samples from many cancer types have been analysed by the team, and about 60 research projects have been conducted within the CIT program thus far. This work has already led to numerous scientific publications and are regularly presented at international scientific meetings.