After the development of a molecular classification of colorectal cancers internationally accepted, the CIT team is developing a diagnostic and predictive tool to improve the care of patients suffering from these cancers. The first results on the validation of this tool will be presented at the International Congress of the American Association of Clinical Oncology (ASCO), which will take place in Chicago from 2 to 6 June 2017. The ASCO meeting is the most important world congress dedicated to clinical oncology.

The CIT team, in collaboration with the team of Pierre Laurent-Puig, a gastroenterologist at the Georges Pompidou European Hospital in Paris (Inserm UMR-S775, Paris), is developing a tool for the clinical use of the molecular classification of colorectal cancers (1, 2). The utility of this tool for the diagnosis and the prediction of the response to treatment is the object of validation studies carried out on large cohorts of patients. A first study was performed on a cohort of more than 1,700 patients, with or without the targeted treatment Cetuximab, the PETACC-8 clinical trial sponsored by the French Federation of Digestive Cancer (FFCD). The first results of this work have been selected for oral presentation at the ASCO 2017 meeting. This presentation will take place on the morning of Tuesday 6 June at the Clinical Science Symposium: Making Sense of Consensus Molecular subtypes. With nearly 30,000 participants, the ASCO meeting is the opportunity of major announcements for the evolution of clinical practices in oncology.

(1) L. Marisa et al., 2013, Plos Medicine
(2) J. Guinney et al., 2015, Nature Medicine
(3) ASCO, American Society of Clinical Oncology, Annual Meeting 2017